Waterford Upstart transformed early childhood education by serving 185,306 children across all 50 states over five years, achieving 89% kindergarten readiness rates while specifically targeting underserved rural, BIPOC, and low-income families through personalized adaptive technology, securing $171 million in public funding for continued nationwide scaling.

Woods Hole Oceanographic Institution's Ocean Twilight Zone Project developed over 40 new technologies to explore the mesopelagic region and established the world's first Ocean Twilight Zone Observation Network spanning 150,000 square miles. They also engaged policymakers at climate conferences to inform international agreements including the UN High Seas Treaty.

Permafrost Pathways advanced critical Arctic climate science in 2024, installing four new carbon monitoring towers and revealing the Arctic tundra has shifted from carbon sink to source. Their co-production approach with 10 Alaska Native communities generated groundbreaking flood models while influencing policy through the briefing of 19 federal agencies and departments.

Upstream USA advanced contraceptive healthcare access in 2024, partnering with 209 healthcare organizations across 34 states serving 1.1 million patients annually. Their evidence-based program achieved a 237% increase in reproductive health screening and 49% increase in contraceptive services, with 93% of patients reporting autonomous decision-making without pressure.

Thorn transformed the fight against child sexual exploitation by building AI-powered tools that process over 25 billion files monthly across 80 major tech companies. Their work contributed to reducing law enforcement investigation time by 60%, helped 70% of global dark web investigators across 48 countries identify child victims faster and they secured commitments from leading AI companies to prevent their models from creating synthetic abuse material.

Think of Us transformed child welfare policy in 2024, influencing all 50 states to adopt new kinship care standards that unlock $3 billion in federal funding. Their Lived Experience Engine captured insights from 51,000+ individuals, directly informing major legislation and California's historic $896 million foster care investment increase.

The Nature Conservancy's Blue Bonds program refinanced $1.2 billion in sovereign debt, unlocked $393 million for conservation, secured commitments for improved ocean management across 41.3 million hectares, established 6.8 million hectares of new ocean conservation commitments, and expanded from a single test case in Seychelles to an established program now launching projects in the Caribbean and exploring opportunities in the Indo-Pacific region.

The END Fund's Deworming Innovation Fund delivered 200M+ treatments across Ethiopia, Kenya, Rwanda, and Zimbabwe, achieving high coverage (roughly 90%+ in most priority rounds), and mobilized government financing, catalyzed $36.4M total and expanded domestic budgets.

The Bail Project posted over $81 million in free bail assistance for 30,553 people across dozens of jurisdictions across the US, achieving a 92% court appearance rate that demonstrates that money is not what makes people return to court. They also helped clients achieve a 35% case dismissal rate with over 91% of bail funds revolving back to support additional clients, preventing 1,184,048 days of pretrial incarceration saving taxpayers $92 million.

The Tenure Facility secured measurable progress toward land tenure rights across 33.7 million hectares in 2024, benefiting over 10,000 communities across 18 countries. Through partnerships with Indigenous, Afro-descendant, and local community organizations, they disbursed $30 million while achieving formal recognition of 4.4 million hectares of ancestral territories.

The Accelerate programme has reduced trachoma risk for approximately 17.2 million people across 14 countries through comprehensive elimination efforts, with Benin becoming the first country to achieve WHO validation for trachoma elimination in 2023.

The Salk Harnessing Plants Initiative has identified 347 gene candidates for enhancing carbon sequestration in crops, with 22 of these genes currently being translated into major food crops like rice, canola, and soybean through genetic modification and field testing - representing the critical transition from laboratory discovery to real-world deployment of plants that could significantly reduce atmospheric CO2.

SIRUM achieved record 2.7x growth in 2024, connecting 274,000 patients with $67 million in redistributed medicine. Through innovative warehouse automation and expanded specialty drug programs, they've now served over 800,000 patients since founding, transforming surplus medication into life-saving access across 11 states while building sustainable redistribution infrastructure.

Restore Local supported 96 restoration champions across three African landscapes in 2024, funding projects that planted 7.9 million trees and created over 25,400 jobs. To date, they’ve catalyzed $41.8 million of additional investment in restoration and through TerraFund, they have provided grants to 81 community organizations and invested debt and equity into 22 enterprises.

One Acre Fund served 2.1 million farmers through core programs and 3.4 million via partnerships in 2024, generating $102 additional income per farmer. Their tree-planting initiative reached 250 million cumulative trees planted, supporting climate resilience while helping farmers achieve 35% higher profits than non-clients across Africa.

Project CETI revolutionized interspecies communication by deploying advanced robotics and machine learning to decode sperm whale language, discovering the first phonetic alphabet and vowels in a non-human species. They have also built local capacity in Dominica through marine conservation fellowships and contributed to groundbreaking scientific publications that are reshaping our understanding of animal communication and laying the foundation for the first-ever Sperm Whale Language Mode.

Noora Health trained 16.4 million caregivers and patients across four countries in 2024, supporting over 10.4 million patients. Their Care Companion Program operates in 12,169 facilities, demonstrating significant health outcomes including 56% reduction in newborn readmissions and 71% reduction in post-surgical complications through family-centered healthcare training.

myAgro served 360,000 farmers across Mali, Senegal, and Côte d'Ivoire in 2024, with 68% being women. Farmers achieved impressive yield increases (167% in Mali and 349% in Senegal) generating $89 additional income on average. The platform planted 949,000 trees and signed government partnerships to scale agricultural transformation.

Living Goods supported 12,041 community health workers serving 6.8 million people across Kenya, Uganda, and Burkina Faso. Treated or referred 3.57 million sick children under 5 and achieved 92% full immunization rates for children 9-23 months. Successfully piloted Kenya's first electronic community health information system approved for national scale to all 95,000 CHWs across the country.

Last Mile Health revolutionized rural healthcare access by professionalizing over 23,000 community health workers across four African countries to serve nearly 37 million people. Their "Six S" framework (salaried, supplied, skilled, supervised, scaled, and systematically integrated) became global best practice and they co-launched the Africa Frontline First initiative that has unlocked $240 million in financing across 17 countries so far.

Jan Sahas' Migrants Resilience Collaborative initiative registered 6.73 million vulnerable migrant households across 96 districts in 12 Indian states, facilitating 6.76 million benefits worth $193 million. Their 24/7 helpline received 216,000 calls, rescued 3,600 workers from forced labor, and partnered with 6 state governments to strengthen social protection systems.

The Humanitarian OpenStreetMap Team transformed global crisis response by mobilizing 750,000 mappers across 60+ countries to map areas home to one billion people. They created the industry-standard open-source geospatial datasets that represent 40% of all datasets on UN's Humanitarian Data Exchange portal, and developed cutting-edge mapping technologies that democratize data collection in low-resource settings and influence hundreds of millions in government spending.

The International Refugee Assistance Project provided legal aid to over 3,700 displaced people from 63 countries, achieving an 88% positive outcome rate. Through partnerships with 505 organizations worldwide, they benefited over 1 million displaced individuals with legal information, systemic advocacy, and training. Their work unlocked $18.4 million in pro bono legal services.

The Institute for Protein Design revolutionized protein engineering by delivering the world's first computer-generated protein medicine, a COVID-19 vaccine approved in the UK and South Korea, and they are advancing candidate vaccines for flu and other diseases through their breakthrough nanoparticle platform technology. They've also raised over $1 billion through spinouts and their vaccine design company was acquired by AstraZeneca for $1.1. And David Baker was awarded the 2024 Nobel Prize.

Innovative Genomics Institute identified methane-reducing targets in cow microbiomes, recovered hundreds of unique rumen plasmids for DNA delivery, and developed inflammatory biomarkers predicting infant asthma development.

Global Fishing Watch mapped 100% of industrial fishing fleets and shipping vessels using AI and satellite technology, revealing 75% of fishing vessels are not publicly tracked. Their free, open platform now monitors 1.2 million square kilometers and they are currently partnering with 20 governments to enhance ocean management while supporting groundbreaking research and enforcement actions.

Global Methane Hub deployed $100.2M in 2024 alone, totaling $250 million invested across 227 grants in three years. They contributed to securing China's first methane action plan, to the launch of the MethaneSAT and Carbon Mapper satellites, and to growing the Global Methane Pledge to 121 member nations.

Educate Girls successfully enrolled 1.56 million out-of-school girls, achieving a 90% year-on-year retention rate. They delivered learning gains equivalent to over two additional years of schooling, and created lasting systems change by embedding their methodology in government programs across multiple states, and building a network of 30,000+ community volunteers that continues to champion girls' education even after program completion.

GirlTrek powered Black women's health by training over 10,000 public health activists and engaging 1.2 million Black women in daily walking routines. Their community-centered approach achieved remarkable results: 67% of members reported improved health conditions, with 56% no longer requiring medications, while earning national recognition including a 2023 Webby Award.

Glasswing's SanaMente program trained 45,503 frontline workers across Latin America in trauma-informed care, reaching 5.1 million citizens. 94% of participants apply self-regulation techniques while 79% integrate trauma-informed approaches, transforming healthcare, education, and law enforcement systems.

Food4Education is scaling affordable school nutrition across Kenya and are currently serving 357,000 children daily. Partnering with county governments, they've achieved remarkable outcomes including 67% increased attendance, enrollment growth across all four counties, and created 3,500 jobs while advancing toward feeding 1 million children by 2027.

Every Cure's MATRIX platform has identified promising candidates including arginine for sickle cell disease, leucovorin for a subgroup of autism spectrum disorder, and lidocaine for cancer, advancing toward their goal of shifting clinical practice for 15-25 undertreated diseases.

EDF's MethaneSAT launched successfully in March 2024, delivering unprecedented, freely available methane imaging that pinpointed super-emitters and diffuse sources across global oil and gas regions. After little over a year of breakthrough data collection, contact was lost in June 2025, and the satellite is likely unrecoverable. Yet its validated methods and datasets continue driving action.

Code for America's Safety Net Innovation Lab helped 6.6 million Americans access $8 billion in benefits across 14 states, Washington D.C., and the Cherokee Nation. In 2024 alone, they supported 2.58 million people receiving $4.3 billion in benefits.

Collins Lab and Phare Bio pioneered the first AI-generated antibiotics against MRSA and gonorrhea showing 16x greater potency and 10x lower cytotoxicity. They secured $31 million in funding including a $27 million ARPA-H award, advanced 4 AI-generated drug programs, and are building the first open-source database for AI-based antibiotic discovery.

Drive Electric Campaign achieved 19% global EV sales for passenger vehicles in 2024, securing commitments covering 41% of global road transportation demand. Through 441 grants across 76 countries, they supported 129 policy actions globally, catalyzing zero-emission vehicle adoption and delivering massive climate, health, and economic benefits worldwide.

Crisis Text Line supported 2.26 million global conversations in 2024, maintaining 82% satisfaction rates while serving primarily underrepresented communities: 67% under age 24, 52% LGBTQ+, and 45% BIPOC. They achieved their first financial break-even financial year and are launching Spanish-language services across 20 countries in 2025.

The Clean Slate Initiative secured Clean Slate legislation in 12 states making over 15 million people eligible for record clearance. They also demonstrated measurable impact with 42% of people with automatically sealed records reporting employment improvements and launched a bipartisan federal coalition of 42 organizations from across the political and social spectrum.

Center for Tech and Civic Life's US Alliance for Election Excellence established 26 voluntary, nonpartisan standards defining election excellence across America. They supported 10 Centers for Election Excellence serving 3.9 million voters and created 28 publicly available resources empowering over 1,100 election officials nationwide. Since 2023, they've catalyzed $588 million in public funding.

BRAC's Ultra-Poor Graduation Initiative established formal partnerships with governments in seven countries, including launching the world's first government-led urban Graduation program in Bihar with a $47 million government budget serving 18,000 households. They also leveraged a $110 million philanthropic investment to mobilize $5 billion in government funding with projected $6-55 billion in economic benefits.

Canopy secured commitments from 951 brands for sustainable sourcing policies, mobilized 698,000 tonnes of Next Generation fiber commitments, achieved 8.36 million tonnes of annual Next Gen production with $530 million in new investments, and drove two major Chinese viscose producers to launch commercial pilot facilities targeting 2027 scale-up.

ACEGID & Broad's Sentinel strengthened West Africa’s frontline disease defense by training nearly 2,000 scientists and public health officials, delivering about 250,000 clinic-based diagnostic tests for priority infections, onboarding 9,400 patients into real-time surveillance, generating hundreds of genomes to track outbreaks (including malaria drug-resistance markers), guiding Nigeria’s mpox vaccine targeting, and standing up advanced lab capacity to safely study dangerous pathogens and run ultra–high-throughput sequencing.

The Center for Policing Equity collaborated with over 60 police departments, supporting over 96 million people through public safety improvement efforts, and expanded community empowerment programs to 50 cities across 28 states through their Unlocking Democracy initiative.

CAMFED supported 738,674 vulnerable girls with comprehensive education support, achieving exceptional retention with 97% progression rates and 95% completion rates for upper secondary. They also created lasting systems change by establishing the Learner Guide program in 7,537 government schools, securing 50 MOUs with ministries, and building a network of 312,747 young women leaders who provided support to over 500,000 additional girls through their own philanthropy and community leadership.